The collection comprises the personal papers and organizational records of Mississippi civil rights activist Edgar Sandifer, 1929-2014. Organizational materials consist of his administrative, financial, promotional, and legal records as part of the Mississippi Gay Alliance (MGA), Persons with AIDS/HIV Project (PWA), Jackson Gray Panthers (JGP), and People's Anti-War Mobilization (PAM). The administrative files include meeting minutes, memoranda, correspondence, notes, and by-laws. Financial materials include bank statements, treasurer reports, expense reports, budgets, tax documents, and grant and funding applications. Promotional materials include newsletters, articles, press releases, brochures, publications, and counseling services materials. Legal materials include charters of incorporation, deeds of trust, contracts, and legal defense materials.

The MGA series, 1971-1998, documents the organization's administrative history; the affiliations and resources utilized to provide and support the organization's services; the memberships and chartered corporations with which the organization was directly associated; the MGA newsletter; and topical resources relating to gay issues and events. The PWA series, 1961-1996, documents the organization's administrative history; the affiliations and resources utilized to provide and support the organization's services; and the services provided to those with AIDS-related illnesses and needs. The JGP series, 1975-1996, documents the organization's administrative history and the services it provided to the elderly. The PAM series, 1974-1996, includes promotional items, publications, and correspondence regarding labor rights and anti-war programs.

The Personal papers series, 1929-1997, consists of awards, holiday cards, military documents, familial data, and a personal diary. The Audiovisual materials series consists of photographs and audiocassettes of Sandifer's life and work, 1948-1995, including recorded interviews and images of weddings, drag shows, official public appearances, and social gatherings with friends and family. The Newspaper clippings series, 1966-1995, includes materials from local Mississippi newspapers regarding Sandifer's advocacy work and his general interest in topics such as racism, AIDS, and homophobia. The Memorabilia series, 1974-1989, consists of banners, t-shirts, name badges, needle work, and posters among other materials.